Ibutamoren MK-677 Review | Accurate Dosage, Side Effects, Before & After Results

Photo of author
Written By Jonathan Deventer

What Is Ibutamoren (MK-677)

Ibutamoren MK-677 Results

Ibutamoren Mesylate is a medication used to boost metabolism and bone strength. This compound has been associated with vast health benefits, but strangely, when you try to search it online, you are likely to come across more discussion forums about it than actual clinical trials.

This, therefore, makes it somewhat challenging to tell what it can do with typical online propaganda.

In the few clinical studies we’ve seen so far, there are promising details that point towards the compound’s ability to improve insulin growth factor 1 (IGF-1) and growth hormone levels.

When Ibutamoren is introduced into your body, it works similarly to the hormone ghrelin. The compound then attaches itself to the ghrelin receptors (GHSR) found in the brain.

This activates the receptors stimulating the release of growth hormone from the brain.

GHSR is located in the brain areas tasked with controlling mood, biological rhythms, pleasure, appetite, cognition, and memory.

This has always been a subject of heated debate when discussing the effects of Ibutamoren on brain performance.

Studies, however, show that the only thing affected by the presence of this compound in GHSR is an increase in appetite.

So far no reliable studies have been able to show how MK-677 can influence the rise or decline of any of the other factors controlled in this part of the brain.

What makes using Ibutamoren fantastic is how it selectively influences an increase in growth hormone without affecting the secretion of other hormones in the brain.

Users of Mk-677 can hence safely take the drug without having to worry about whether levels of other hormones like cortisol (which reduces the effectiveness of the immune system) will increase.

How Does Ibutamoren (MK-677) Work?


Ibutamoren Mesylate functions like a growth hormone pulse booster. As such, it is capable of influencing the production and levels of the essential hormone in the body through various clinically proven ways:

  • It stimulates your body to release more growth hormone releasing hormone or GHRH.
  • As the levels of GHRH go high, the compound goes further to amplify signal transmission in the somatotrophs located in the anterior pituitary gland. This helps in increasing levels of growth hormone in the body.
  • One of the biggest reasons for the decrease in growth hormone levels in the body is the presence of somatostatin. When this chemical is released into the body it will not just slow down the release of growth hormone but can even go as far are stopping its release altogether. Ibutamoren helps to inhibit the release of somatostatin and will also prevent or stop communication of somatostatin receptors thus blocking the expression of its effects.

Ibutamoren (MK-677) Benefits

Ibutamoren MK-677 Benefits
  • Improves Muscles Mass

Ibutamoren is an exceptional anabolic substance. One of the biggest uses of Ibutamoren is for the bulking up of muscles.

The compound can quickly be taken orally, and users only need to use it once a day to enjoy benefits such as an increase in muscle strength and mass and reducing body fat.

Obese men can also experience an increase in lean mass and basal metabolic rate after just two months of using it.

  • Increase in Bone Density

An increase in growth hormone will naturally lead to improved bone density. This is, however, not something you’ll notice overnight or after just a few times of using Mk-677.

It’s a long-term benefit that might even take up to a year to witness. Studies have shown that the use of ibutamoren in healthy obese men led to improved bone turnover while elderly adults observed increased bone building.

Post-menopausal women using Ibutamoren will also benefit from the boosted bone mineral density that prevents osteoporosis and leads to an increase in bone strength.

  • Prevents Muscle Wasting

A decrease in proteins be it due to poor diet, or other issues can very quickly lead to muscle wasting. Ibutamoren will reverse such effects promoting gait speed and muscle strength in no time.

  • Promotes Quality Sleep

Your brain won’t be able to focus efficiently on the gym or any other activities if you are not getting sufficient sleep.

Ibutamoren understands the importance of high-quality sleep, and that’s why the compound is also formulated to deliver that.

This is a benefit backed by various clinical trials and further supported by multiple user testimonials online.

  • Can improve cognitive performance

There are reports that using Ibutamoren can deliver cognitive benefits but there are very limited studies to prove this.

It is believed that since the compound affects ghrelin receptors that influence brain functioning using MK-677 to impact the performance of these receptors could consequently improve your cognitive abilities.

Mk-677 also increases levels of IGF-1 in the body a chemical that controls learning and memory, and this adds to the speculations that Ibutamoren has nootropic benefits.

We, however, need more scientific studies to provide a direct link between Ibutamoren and brain performance.

  • Provides anti-aging benefits

Once you hit your 30s going forward, the production of growth hormone starts declining. This is what results in cases such as loss of hair, skin elasticity, bone density, and many other effects.

Since Ibutamoren increases levels of growth hormone in the body, the user will be able to enjoy better cell regeneration thus combating the effects of aging.

  • Boosts tissue regeneration and wound healing

Tissue regeneration and the healing of wounds become problematic when we age, and this is partly due to low levels of growth hormone in the body.

Once supplemented by a product like Ibutamoren, wounds will heal faster because the high levels of a growth hormone enhance tissue regeneration.

  • Treating growth hormone deficiency

Growth hormone deficiency is quite a severe problem, especially in children. Ibutamoren has been used to treat this deficiency where it helps with increasing growth hormone, IGFBP-3, and IGF-1.

What makes it even more ideal for use in children is that it’ll boost growth hormone levels without touching glucose, thyroxine (T4), Triiodothyronine (T3), prolactin, insulin, cortisol, or thyrotropin levels.

The compound can also be used to treat growth hormone deficiency in men where it works almost in a similar manner as it does in children except in adults, glucose, and insulin levels are also likely to be affected.

MK-677 Ibutamoren Dosage

Ibutamoren MK-677 Dosage

The dosage necessary for optimal performance of Ibutamoren ranges from one individual to another. It’s for this reason that the recommended dosage also varies from 5-25mgs daily.

You are required to find the proper dosage for you within this range and stick to it. Beginners are advised to start at just 5mg daily and then work their way up slowly.

Some people use even higher dosages, but you shouldn’t do this unless you are sure your body can handle it.

Ibutamoren (MK-677) Side Effects

Ibutamoren MK-677 Side Effects

Yes, usage of Ibutamoren has been associated with various side effects majority of which are similar to those experienced by people with excessive growth hormone in the body.

These include; increase in appetite, muscle pain, and subtle lower extremity edema. A few studies also pointed out the possibility of seeing a decrease in insulin sensitivity, and an increase in blood glucose.

In elderly patients (at least 80 years old) cases of high blood glucose, pressure and HbA1c are also prevalent.

Users of Ibutamoren are advised to check their blood sugar and insulin levels regularly. Watching carbohydrate intake is also essential.

Cancer patients are discouraged from taking Ibutamoren as it can boost cancer growth. Th1 Dominant individuals should also stay away from Mk-677.

Clinical Research

Ibutamoren MK-677 clincal trial

So much is said about Ibutamoren, and that’s why we began by stating that it is rather difficult to differentiate what’s real from what isn’t.

Going through the limited information available, we have fortunately discovered that benefits such as muscle growth and endurance are undebatable here.

This is why Ibutamoren is relied upon by hundreds of bodybuilders and athletes out there for their day-to-day performance.

The fact that it can be utilized orally gives it an upper hand against typical steroids that demand injections.

What’s even more brilliant is that, unlike these steroids that leave people nursing severe side effects, Ibutamoren is much safer especially if used correctly.

For full disclosure, you should know that benefits such as treating osteoporosis, obesity, and hip fractures are all still under investigation.


If you want to boost your endurance, energy, strength, and bone density, then Ibutamoren is what you need.

Maintaining muscle mass while on a low-calorie diet has never been any easier thanks to MK-677.

The compound’s ability to increase your growth hormone levels will not just benefit you in the gym but will also help to keep you generally healthy. Ibutamoren stacks well with Ostarine.

Buy Ibutamoren MK-677

Legal Alternative to Ibutamoren (MK-677)

Ibutamoren MK-677 Alternative
  • Increases longevity
  • Increases bone strength
  • Enhances muscle recovery
  • Prevents tumor growth
  • Increases stamina
  • No negative side effects

Related Articles:

Leave a Comment